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Strontium in PDB 4ij0: Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation

Protein crystallography data

The structure of Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation, PDB code: 4ij0 was solved by F.Zhang, K.Suzuki, M.Tsunoda, O.Wilkinson, C.L.Millington, D.M.Williams, E.C.Morishita, A.Takenaka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.92 / 1.54
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 24.600, 41.230, 63.070, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / 23.7

Strontium Binding Sites:

The binding sites of Strontium atom in the Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation (pdb code 4ij0). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 3 binding sites of Strontium where determined in the Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation, PDB code: 4ij0:
Jump to Strontium binding site number: 1; 2; 3;

Strontium binding site 1 out of 3 in 4ij0

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Strontium binding site 1 out of 3 in the Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Sr101

b:23.9
occ:1.00
O B:HOH209 2.4 28.4 1.0
O A:HOH505 2.5 20.1 1.0
O B:HOH206 2.6 20.1 1.0
O A:HOH520 2.6 18.9 1.0
O A:HOH509 2.6 23.7 1.0
O A:HOH511 2.6 24.2 1.0
O A:HOH570 2.7 23.5 1.0
O B:HOH223 2.8 25.1 1.0
O B:HOH210 4.1 33.5 1.0
O2 A:DC9 4.2 17.8 1.0
O A:HOH526 4.4 19.5 1.0
O A:HOH546 4.5 39.5 1.0
O4' A:DC11 4.8 17.1 1.0
O B:HOH227 4.8 39.0 1.0
O4' A:DG10 4.9 18.6 1.0
N3 A:DG10 5.0 11.7 1.0

Strontium binding site 2 out of 3 in 4ij0

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Strontium binding site 2 out of 3 in the Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Sr102

b:25.5
occ:1.00
O B:HOH257 2.4 17.9 1.0
O B:HOH251 2.4 31.9 1.0
O B:HOH255 2.5 26.9 1.0
O A:HOH569 2.5 22.3 1.0
O A:HOH502 2.6 19.1 1.0
O A:HOH556 2.7 30.2 1.0
O B:HOH252 3.3 30.5 1.0
O6 B:DG22 4.2 13.6 1.0
O A:HOH513 4.5 23.5 1.0
O B:HOH256 4.6 28.7 1.0
O A:HOH508 4.6 27.4 1.0
O A:HOH530 4.6 21.7 1.0
N4 A:DC3 4.6 18.1 1.0
O A:HOH555 4.7 28.6 1.0
O B:HOH239 4.7 31.2 1.0
N7 A:DG2 5.0 10.4 1.0

Strontium binding site 3 out of 3 in 4ij0

Go back to Strontium Binding Sites List in 4ij0
Strontium binding site 3 out of 3 in the Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 3 of Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Transition Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Sr103

b:32.0
occ:1.00
O A:HOH514 2.3 25.3 1.0
O A:HOH536 4.3 30.6 1.0

Reference:

F.Zhang, M.Tsunoda, K.Suzuki, Y.Kikuchi, O.Wilkinson, C.L.Millington, G.P.Margison, D.M.Williams, E.Czarina Morishita, A.Takenaka. Structures of Dna Duplexes Containing O6-Carboxymethylguanine, A Lesion Associated with Gastrointestinal Cancer, Reveal A Mechanism For Inducing Pyrimidine Transition Mutations Nucleic Acids Res. V. 41 5524 2013.
ISSN: ISSN 0305-1048
PubMed: 23580550
DOI: 10.1093/NAR/GKT198
Page generated: Wed Dec 16 02:23:59 2020

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