Strontium in PDB 8cv8: Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine

All present enzymatic activity of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine:
1.14.11.11;

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine, PDB code: 8cv8 was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.87 / 1.53
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.851, 79.25, 56.019, 90, 111.12, 90
R / Rfree (%)	18.1 / 20.8

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine also contains other interesting chemical elements:

Iron

(Fe)

1 atom

The binding sites of Strontium atom in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine (pdb code 8cv8). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine, PDB code: 8cv8:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr401 b:22.7 occ:0.76 O A:ASN145 2.5 17.9 1.0 O A:HOH739 2.5 36.7 1.0 O A:HOH537 2.5 36.2 1.0 O A:HOH723 2.6 33.0 1.0 O A:HOH697 2.6 24.5 1.0 O A:HOH668 2.7 25.9 1.0 C A:ASN145 3.6 17.6 1.0 CA A:SER146 4.3 16.1 1.0 OE2 A:GLU149 4.3 23.6 1.0 NH2 A:ARG155 4.4 14.4 1.0 N A:SER146 4.4 16.7 1.0 CA A:ASN145 4.7 18.7 1.0 O A:HOH534 4.7 29.7 1.0 O A:HOH775 4.7 33.0 1.0 CB A:ASN145 4.7 20.5 1.0

Strontium binding site 2 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr402 b:10.5 occ:0.94 OE1 A:GLN95 2.5 14.0 1.0 O A:GLY98 2.5 12.0 1.0 O A:HOH562 2.6 16.5 1.0 OE2 A:GLU92 2.6 13.7 1.0 OE1 A:GLU92 2.8 13.2 1.0 CD A:GLU92 3.1 13.4 1.0 CD A:GLN95 3.5 13.9 1.0 C A:GLY98 3.6 12.3 1.0 NE2 A:GLN95 4.0 14.7 1.0 CA A:GLY98 4.4 12.6 1.0 O2 A:FMT412 4.5 38.8 1.0 N A:GLU99 4.5 12.6 1.0 CA A:GLU99 4.5 13.5 1.0 CG A:GLU92 4.6 13.1 1.0 O A:HOH631 4.8 24.2 1.0 CG A:GLN95 4.8 13.1 1.0 CB A:GLN95 4.8 12.9 1.0 O A:HOH606 4.9 12.1 1.0

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure of the H6H Hydroxylation Reactant Complex To Be Published.