Strontium in PDB 8cva: Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine

All present enzymatic activity of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine:
1.14.11.11;

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cva was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.61 / 1.58
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.839, 79.258, 55.96, 90, 111.22, 90
R / Rfree (%)	18.5 / 20.6

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine also contains other interesting chemical elements:

Iron

(Fe)

1 atom

The binding sites of Strontium atom in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine (pdb code 8cva). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cva:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr415 b:27.1 occ:0.76 O A:ASN145 2.5 17.9 1.0 O A:HOH719 2.5 35.7 1.0 O A:HOH554 2.5 34.9 1.0 O A:HOH711 2.6 33.7 1.0 O A:HOH696 2.6 28.0 1.0 O A:HOH648 2.8 25.0 1.0 C A:ASN145 3.6 18.0 1.0 CA A:SER146 4.3 16.8 1.0 N A:SER146 4.3 17.2 1.0 NH2 A:ARG155 4.4 14.2 1.0 OE2 A:GLU149 4.4 24.3 1.0 CA A:ASN145 4.6 18.8 1.0 O A:HOH750 4.7 33.4 1.0 O A:HOH507 4.7 30.9 1.0 CB A:ASN145 4.7 20.1 1.0 O A:HOH755 4.8 33.6 1.0

Strontium binding site 2 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr416 b:10.6 occ:0.97 O A:GLY98 2.5 13.2 1.0 OE1 A:GLN95 2.5 12.4 1.0 OE2 A:GLU92 2.7 12.3 1.0 O A:HOH715 2.7 15.2 1.0 OE1 A:GLU92 2.8 11.9 1.0 CD A:GLU92 3.1 12.2 1.0 CD A:GLN95 3.5 12.7 1.0 C A:GLY98 3.6 13.0 1.0 NE2 A:GLN95 4.0 13.3 1.0 CA A:GLY98 4.4 13.1 1.0 N A:GLU99 4.5 13.0 1.0 CA A:GLU99 4.5 13.3 1.0 CG A:GLU92 4.6 12.3 1.0 CG A:GLN95 4.8 12.3 1.0 CB A:GLN95 4.8 12.2 1.0 O A:HOH649 4.9 21.3 1.0 O A:HOH626 5.0 11.9 1.0

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure of the H6H Hydroxylation Product Complex To Be Published.