Strontium in PDB 8cvb: Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine

All present enzymatic activity of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine:
1.14.11.11;

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine, PDB code: 8cvb was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.61 / 1.53
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.801, 79.329, 55.848, 90, 110.99, 90
R / Rfree (%)	18.3 / 20.4

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine also contains other interesting chemical elements:

Iron

(Fe)

1 atom

The binding sites of Strontium atom in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine (pdb code 8cvb). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine, PDB code: 8cvb:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr418 b:23.0 occ:0.75 O A:ASN145 2.4 16.8 1.0 O A:HOH743 2.5 34.6 1.0 O A:HOH590 2.6 33.4 1.0 O A:HOH739 2.6 30.6 1.0 O A:HOH718 2.6 25.8 1.0 O A:HOH665 2.7 26.7 1.0 C A:ASN145 3.6 16.7 1.0 CA A:SER146 4.3 15.4 1.0 NH2 A:ARG155 4.3 13.5 1.0 OE2 A:GLU149 4.4 22.0 1.0 N A:SER146 4.4 16.0 1.0 CA A:ASN145 4.7 17.8 1.0 CB A:ASN145 4.8 19.3 1.0 O A:HOH781 4.8 32.2 1.0 O A:HOH516 4.8 30.2 1.0 O A:HOH510 5.0 24.7 1.0

Strontium binding site 2 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2- Oxoglutarate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr419 b:10.0 occ:0.96 OE1 A:GLN95 2.5 13.5 1.0 O A:GLY98 2.5 11.6 1.0 O A:HOH731 2.6 16.9 1.0 OE2 A:GLU92 2.6 12.1 1.0 OE1 A:GLU92 2.8 11.7 1.0 CD A:GLU92 3.1 12.0 1.0 CD A:GLN95 3.5 13.1 1.0 C A:GLY98 3.6 12.1 1.0 NE2 A:GLN95 4.0 13.8 1.0 CA A:GLY98 4.4 12.2 1.0 N A:GLU99 4.5 12.3 1.0 O2 A:FMT407 4.5 56.0 1.0 CA A:GLU99 4.5 12.9 1.0 CG A:GLU92 4.6 12.1 1.0 C A:FMT407 4.6 56.5 1.0 O1 A:FMT407 4.7 57.5 1.0 CG A:GLN95 4.8 12.6 1.0 CB A:GLN95 4.9 12.4 1.0 O A:HOH701 4.9 21.0 1.0 O A:HOH600 4.9 11.0 1.0

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure of the H6H Cyclization Reactant Complex To Be Published.