Strontium in PDB 8cvg: Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine

Enzymatic activity of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine

All present enzymatic activity of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine:
1.14.11.11;

Protein crystallography data

The structure of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine, PDB code: 8cvg was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	43.57 / 1.56
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	44.719, 79.228, 55.822, 90, 111.03, 90
*R / R_free (%)*	18.2 / 20.1

Other elements in 8cvg:

The structure of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine also contains other interesting chemical elements:

Iron

(Fe)

1 atom

Strontium Binding Sites:

The binding sites of Strontium atom in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine (pdb code 8cvg). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine, PDB code: 8cvg:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in 8cvg

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Strontium Binding Sites List in 8cvg

Strontium binding site 1 out of 2 in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine

Mono view

Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Sr420 b:10.7 occ:0.98	O	A:GLY98	2.5	11.3	1.0
	OE1	A:GLN95	2.5	12.4	1.0
	OE2	A:GLU92	2.6	11.7	1.0
	O	A:HOH710	2.6	15.7	1.0
	OE1	A:GLU92	2.8	11.4	1.0
	CD	A:GLU92	3.1	11.3	1.0
	CD	A:GLN95	3.6	12.2	1.0
	C	A:GLY98	3.6	11.7	1.0
	NE2	A:GLN95	4.0	12.7	1.0
	CA	A:GLY98	4.4	11.9	1.0
	N	A:GLU99	4.4	11.7	1.0
	CA	A:GLU99	4.5	12.2	1.0
	CG	A:GLU92	4.6	11.4	1.0
	O	A:HOH629	4.8	20.6	1.0
	CG	A:GLN95	4.8	12.1	1.0
	CB	A:GLN95	4.8	11.9	1.0
	O	A:HOH594	4.9	9.9	1.0
	O	A:HOH703	4.9	29.7	1.0

Strontium binding site 2 out of 2 in 8cvg

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Strontium Binding Sites List in 8cvg

Strontium binding site 2 out of 2 in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine

Mono view

Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Iron, 2-Oxoglutarate, and 6-Oh-Hyoscyamine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Sr421 b:24.4 occ:0.60	O	A:ASN145	2.4	17.3	1.0
	O	A:HOH712	2.5	38.5	1.0
	O	A:HOH592	2.5	36.8	1.0
	O	A:HOH700	2.6	27.5	1.0
	O	A:HOH714	2.7	42.0	1.0
	O	A:HOH663	2.8	29.3	1.0
	C	A:ASN145	3.6	17.5	1.0
	CA	A:SER146	4.3	16.0	1.0
	N	A:SER146	4.3	16.6	1.0
	NH2	A:ARG155	4.4	13.4	1.0
	OE2	A:GLU149	4.4	21.9	1.0
	CA	A:ASN145	4.6	18.8	1.0
	CB	A:ASN145	4.7	20.2	1.0
	O	A:HOH507	4.8	26.0	1.0
	O	A:HOH753	4.8	31.5	1.0

Reference:

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure of the L289F H6H Cyclization Reactant Complex To Be Published.

Page generated: Fri Oct 11 07:47:14 2024

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