Strontium in PDB 8cvh: Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine

All present enzymatic activity of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine:
1.14.11.11;

The structure of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cvh was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.75 / 2.03
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.915, 79.102, 56.276, 90, 111.25, 90
R / Rfree (%)	20.1 / 25

The structure of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine also contains other interesting chemical elements:

Vanadium

(V)

1 atom

The binding sites of Strontium atom in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine (pdb code 8cvh). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cvh:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr415 b:17.4 occ:0.93 O A:HOH586 2.5 16.9 1.0 O A:GLY98 2.5 21.1 1.0 OE1 A:GLN95 2.6 21.4 1.0 OE1 A:GLU92 2.7 21.7 1.0 OE2 A:GLU92 2.7 22.0 1.0 CD A:GLU92 3.0 22.2 1.0 C A:GLY98 3.6 22.1 1.0 CD A:GLN95 3.6 22.0 1.0 NE2 A:GLN95 4.1 22.2 1.0 CA A:GLY98 4.4 22.4 1.0 N A:GLU99 4.4 22.0 1.0 CA A:GLU99 4.5 23.5 1.0 CG A:GLU92 4.5 22.6 1.0 CG A:GLN95 4.8 21.5 1.0 CB A:GLN95 4.9 21.3 1.0 O A:HOH548 4.9 38.8 1.0

Strontium binding site 2 out of 2 in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr416 b:50.0 occ:0.88 O A:ASN145 2.5 29.3 1.0 O A:HOH590 2.5 30.4 1.0 O A:HOH577 2.7 24.9 1.0 O A:HOH566 2.7 30.3 1.0 O A:HOH588 2.8 27.1 1.0 C A:ASN145 3.6 29.9 1.0 CA A:SER146 4.3 28.6 1.0 N A:SER146 4.3 29.3 1.0 NH2 A:ARG155 4.3 23.4 1.0 OE2 A:GLU149 4.5 35.8 1.0 CA A:ASN145 4.6 30.3 1.0 CB A:ASN145 4.8 32.0 1.0 O A:HOH600 4.9 33.0 1.0 C A:SER146 4.9 27.1 1.0

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure of the L289F H6H Cyclization Ferryl-Mimicking Complex To Be Published.