Strontium in PDB 8or6: Crystal Structure of Drosophila Melanogaster Alpha-Amylase

All present enzymatic activity of Crystal Structure of Drosophila Melanogaster Alpha-Amylase:
3.2.1.1;

The structure of Crystal Structure of Drosophila Melanogaster Alpha-Amylase, PDB code: 8or6 was solved by N.Aghajari, R.Haser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.78 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	80.44, 73.09, 99.29, 90, 98.27, 90
R / Rfree (%)	20.8 / 26.6

The structure of Crystal Structure of Drosophila Melanogaster Alpha-Amylase also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Strontium atom in the Crystal Structure of Drosophila Melanogaster Alpha-Amylase (pdb code 8or6). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 4 binding sites of Strontium where determined in the Crystal Structure of Drosophila Melanogaster Alpha-Amylase, PDB code: 8or6:
Jump to Strontium binding site number: 1; 2; 3; 4;

Strontium binding site 1 out of 4 in the Crystal Structure of Drosophila Melanogaster Alpha-Amylase


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Crystal Structure of Drosophila Melanogaster Alpha-Amylase within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr502 b:23.8 occ:1.00 OD1 A:ASP156 2.3 25.3 1.0 O A:HIS190 2.4 20.2 1.0 O A:HOH618 2.5 12.9 1.0 O A:ARG147 2.7 26.7 1.0 OD1 A:ASN98 2.8 10.7 1.0 CG A:ASP156 3.0 25.2 1.0 OD2 A:ASP156 3.0 20.4 1.0 C A:ARG147 3.4 30.7 1.0 C A:HIS190 3.6 15.6 1.0 CG A:ASN98 3.9 16.3 1.0 CA A:ARG147 4.0 36.0 1.0 CB A:HIS190 4.2 16.4 1.0 N A:ASN148 4.2 30.4 1.0 ND2 A:ASN98 4.3 11.8 1.0 CG A:MET191 4.4 14.7 1.0 O A:ASN98 4.5 21.8 1.0 CA A:HIS190 4.5 18.5 1.0 CB A:ASP156 4.5 21.4 1.0 N A:MET191 4.6 19.6 1.0 CA A:ASN148 4.6 36.3 1.0 OE1 A:GLN159 4.6 24.3 1.0 O A:LEU157 4.6 30.7 1.0 CA A:MET191 4.6 23.7 1.0 O A:CYS149 4.6 30.3 1.0 O A:VAL146 4.6 23.8 1.0 ND2 A:ASN132 4.8 34.0 1.0 CB A:ARG147 4.9 18.1 1.0 O A:HOH715 4.9 21.0 1.0

Strontium binding site 2 out of 4 in the Crystal Structure of Drosophila Melanogaster Alpha-Amylase


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Crystal Structure of Drosophila Melanogaster Alpha-Amylase within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr503 b:32.9 occ:1.00 OE1 A:GLN263 2.5 20.1 1.0 O A:HOH781 2.5 16.0 1.0 O A:HOH790 2.6 19.8 1.0 O A:HOH827 2.6 20.6 1.0 O A:HOH750 2.7 18.2 1.0 O A:HOH605 2.8 22.4 1.0 CD A:GLN263 3.6 24.2 1.0 NE2 A:GLN263 4.1 23.5 1.0 OD1 A:ASP391 4.7 16.4 1.0 CG A:GLN263 4.7 15.9 1.0 CB A:GLN263 4.8 14.5 1.0

Strontium binding site 3 out of 4 in the Crystal Structure of Drosophila Melanogaster Alpha-Amylase


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 3 of Crystal Structure of Drosophila Melanogaster Alpha-Amylase within 5.0Å range: probe atom residue distance (Å) B Occ B:Sr502 b:26.9 occ:1.00 OD2 B:ASP156 2.4 30.2 1.0 OD1 B:ASP156 2.4 27.2 1.0 O B:HIS190 2.4 17.4 1.0 O B:HOH696 2.6 15.1 1.0 O B:HOH666 2.6 19.6 1.0 CG B:ASP156 2.7 26.5 1.0 OD1 B:ASN98 2.7 18.3 1.0 O B:ARG147 3.0 29.1 1.0 C B:ARG147 3.6 21.6 1.0 C B:HIS190 3.6 16.3 1.0 CG B:ASN98 3.8 18.8 1.0 CA B:ARG147 4.1 27.4 1.0 CB B:HIS190 4.2 15.8 1.0 CB B:ASP156 4.2 20.4 1.0 ND2 B:ASN98 4.3 9.4 1.0 O B:ASN98 4.4 18.1 1.0 CG B:MET191 4.4 18.6 1.0 N B:ASN148 4.5 22.2 1.0 OE1 B:GLN159 4.5 20.1 1.0 CA B:HIS190 4.5 17.2 1.0 O B:LEU157 4.5 21.8 1.0 ND2 B:ASN132 4.5 21.3 1.0 N B:MET191 4.6 19.7 1.0 CA B:MET191 4.6 19.7 1.0 O B:VAL146 4.7 16.7 1.0 O B:CYS149 4.8 29.9 1.0 CA B:ASN148 4.8 29.8 1.0 NE2 B:GLN159 5.0 15.5 1.0 CB B:ARG147 5.0 21.0 1.0

Strontium binding site 4 out of 4 in the Crystal Structure of Drosophila Melanogaster Alpha-Amylase


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 4 of Crystal Structure of Drosophila Melanogaster Alpha-Amylase within 5.0Å range: probe atom residue distance (Å) B Occ B:Sr503 b:41.5 occ:1.00 OE1 B:GLN263 2.4 27.7 1.0 O B:HOH740 2.6 15.4 1.0 O B:HOH786 2.7 13.3 1.0 CD B:GLN263 3.5 22.5 1.0 O B:HOH846 4.0 35.7 1.0 NE2 B:GLN263 4.1 21.3 1.0 OD1 B:ASP391 4.6 17.4 1.0 CG B:GLN263 4.7 19.4 1.0 CB B:GLN263 4.8 17.0 1.0

M.Rhimi, J.L.Da Lage, R.Haser, G.Feller, N.Aghajari. Structural and Functional Characterization of Drosophila Melanogaster Alpha-Amylase. Molecules V. 28 2023.
ISSN: ESSN 1420-3049
PubMed: 37513201
DOI: 10.3390/MOLECULES28145327