Strontium in PDB 8vlh: Crystal Structure of ASH1L Phd-Bah Domains

All present enzymatic activity of Crystal Structure of ASH1L Phd-Bah Domains:
2.1.1.359; 2.1.1.367;

The structure of Crystal Structure of ASH1L Phd-Bah Domains, PDB code: 8vlh was solved by K.R.Vann, A.H.Tencer, T.G.Kutateladze, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.20 / 2.40
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	173.11, 60.575, 53.588, 90, 97.92, 90
R / Rfree (%)	23 / 28.5

The structure of Crystal Structure of ASH1L Phd-Bah Domains also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Strontium atom in the Crystal Structure of ASH1L Phd-Bah Domains (pdb code 8vlh). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total only one binding site of Strontium was determined in the Crystal Structure of ASH1L Phd-Bah Domains, PDB code: 8vlh:

Strontium binding site 1 out of 1 in the Crystal Structure of ASH1L Phd-Bah Domains


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Crystal Structure of ASH1L Phd-Bah Domains within 5.0Å range: probe atom residue distance (Å) B Occ B:Sr2901 b:103.7 occ:1.00 O B:HOH3003 2.9 47.0 1.0 O B:GLU2621 3.1 67.3 1.0 OD2 B:ASP2603 3.4 46.3 1.0 OD1 B:ASP2603 3.4 45.7 1.0 CG B:ASP2603 3.8 44.4 1.0 C B:GLU2621 4.2 65.0 1.0 O B:VAL2620 4.3 66.3 1.0 CA B:GLU2621 4.8 67.6 1.0 O B:HOH3039 4.8 42.1 1.0

K.R.Vann, R.Sharma, C.C.Hsu, M.Devoucoux, A.H.Tencer, L.Zeng, K.Lin, L.Zhu, Q.Li, C.Lachance, R.R.Ospina, Q.Tong, K.L.Cheung, S.Yang, S.Biswas, H.Xuan, J.Gatchalian, L.Alamillo, J.Wang, S.M.Jang, B.J.Klein, Y.Lu, P.Ernst, B.D.Strahl, S.B.Rothbart, M.J.Walsh, M.L.Cleary, J.Cote, X.Shi, M.M.Zhou, T.G.Kutateladze. Structure-Function Relationship of ASH1L and Histone H3K36 and H3K4 Methylation. Nat Commun V. 16 2235 2025.
ISSN: ESSN 2041-1723
PubMed: 40044670
DOI: 10.1038/S41467-025-57556-5