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Strontium in PDB 4iak: Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20

Enzymatic activity of Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20

All present enzymatic activity of Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20:
2.7.11.11;

Protein crystallography data

The structure of Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20, PDB code: 4iak was solved by O.Gerlits, A.Kovalevsky, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.60
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 56.537, 78.924, 97.331, 90.00, 90.00, 90.00
R / Rfree (%) 18.5 / 22.2

Strontium Binding Sites:

The binding sites of Strontium atom in the Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20 (pdb code 4iak). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20, PDB code: 4iak:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in 4iak

Go back to Strontium Binding Sites List in 4iak
Strontium binding site 1 out of 2 in the Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Sr401

b:14.6
occ:1.00
 O1B A:ADP403 2.3 27.2 1.0
O1P S:SEP621 2.4 18.3 1.0
O S:HOH701 2.5 20.7 1.0
O A:HOH1003 2.5 15.1 1.0
O A:HOH1001 2.5 18.8 1.0
O S:HOH702 2.6 18.3 1.0
OD1 A:ASP184 2.6 14.1 1.0
OD2 A:ASP184 2.6 14.5 1.0
CG A:ASP184 3.0 20.3 1.0
PB A:ADP403 3.8 19.3 1.0
P S:SEP621 3.8 17.8 1.0
O A:HOH1002 4.0 14.2 1.0
O3P S:SEP621 4.1 18.0 1.0
CA A:GLY186 4.1 11.4 1.0
SR A:SR402 4.2 15.0 1.0
O S:HOH723 4.3 31.5 1.0
NZ A:LYS72 4.4 15.1 1.0
O2B A:ADP403 4.4 20.7 1.0
O3B A:ADP403 4.5 18.6 1.0
CB A:ASP184 4.5 16.8 1.0
N A:GLY186 4.5 12.3 1.0
OD2 A:ASP166 4.6 17.3 1.0
O2P S:SEP621 4.8 17.7 1.0
O3A A:ADP403 4.8 14.4 1.0
OG S:SEP621 4.9 14.9 1.0
C A:GLY186 5.0 15.7 1.0

Strontium binding site 2 out of 2 in 4iak

Go back to Strontium Binding Sites List in 4iak
Strontium binding site 2 out of 2 in the Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Low Temperature X-Ray Structure of Camp Dependent Protein Kinase A in Complex with High SR2+ Concentration, Adp and Phosphorylated Peptide PSP20 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Sr402

b:15.0
occ:1.00
 O2A A:ADP403 2.4 14.9 1.0
OD2 A:ASP184 2.5 14.5 1.0
O A:HOH1004 2.5 17.6 1.0
O3B A:ADP403 2.6 18.6 1.0
O A:HOH1002 2.6 14.2 1.0
OD1 A:ASN171 2.6 13.3 1.0
O S:HOH703 2.7 15.8 1.0
O1B A:ADP403 3.2 27.2 1.0
PB A:ADP403 3.4 19.3 1.0
CG A:ASP184 3.5 20.3 1.0
CG A:ASN171 3.7 17.9 1.0
PA A:ADP403 3.7 15.9 1.0
O1P S:SEP621 3.9 18.3 1.0
O3A A:ADP403 4.0 14.4 1.0
ND2 A:ASN171 4.0 15.9 1.0
CB A:ASP184 4.0 16.8 1.0
O A:HOH1010 4.2 26.5 1.0
SR A:SR401 4.2 14.6 1.0
O A:HOH1005 4.2 21.4 1.0
CE A:LYS168 4.2 16.8 1.0
NZ A:LYS168 4.4 13.6 1.0
OD1 A:ASP184 4.5 14.1 1.0
O2P S:SEP621 4.6 17.7 1.0
O S:HOH704 4.7 19.9 1.0
O1A A:ADP403 4.7 15.1 1.0
OD2 A:ASP166 4.7 17.3 1.0
C5' A:ADP403 4.7 16.6 1.0
O S:HOH705 4.8 25.9 1.0
O2B A:ADP403 4.8 20.7 1.0
O5' A:ADP403 4.8 15.5 1.0
P S:SEP621 5.0 17.8 1.0
O3' A:ADP403 5.0 18.8 1.0

Reference:

O.Gerlits, M.J.Waltman, S.Taylor, P.Langan, A.Kovalevsky. Insights Into the Phosphoryl Transfer Catalyzed By Camp-Dependent Protein Kinase: An X-Ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry V. 52 3721 2013.
ISSN: ISSN 0006-2960
PubMed: 23672593
DOI: 10.1021/BI400066A
Page generated: Fri Oct 11 05:32:04 2024

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