Strontium in PDB 8cvc: Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine

All present enzymatic activity of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine:
1.14.11.11;

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cvc was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.65 / 1.79
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.911, 79.761, 56.187, 90, 111.05, 90
R / Rfree (%)	17.3 / 19.4

The structure of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine also contains other interesting chemical elements:

Vanadium

(V)

1 atom

The binding sites of Strontium atom in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine (pdb code 8cvc). This binding sites where shown within 5.0 Angstroms radius around Strontium atom.
In total 2 binding sites of Strontium where determined in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cvc:
Jump to Strontium binding site number: 1; 2;

Strontium binding site 1 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 1 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr416 b:15.2 occ:0.95 O A:GLY98 2.5 18.5 1.0 OE1 A:GLN95 2.6 19.1 1.0 O A:HOH687 2.6 23.1 1.0 OE2 A:GLU92 2.6 18.8 1.0 OE1 A:GLU92 2.8 18.6 1.0 CD A:GLU92 3.1 19.0 1.0 C A:GLY98 3.6 17.6 1.0 CD A:GLN95 3.6 19.6 1.0 NE2 A:GLN95 4.1 21.7 1.0 CA A:GLY98 4.3 18.2 1.0 N A:GLU99 4.5 18.3 1.0 CA A:GLU99 4.6 18.7 1.0 CG A:GLU92 4.6 18.8 1.0 O A:HOH648 4.7 36.1 1.0 CG A:GLN95 4.8 18.2 1.0 CB A:GLN95 4.9 17.3 1.0 O A:HOH606 5.0 16.4 1.0

Strontium binding site 2 out of 2 in the Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine


Mono view


Stereo pair view

A full contact list of Strontium with other atoms in the Sr binding site number 2 of Structure of Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Sr417 b:41.7 occ:0.85 O A:ASN145 2.5 22.9 1.0 O A:HOH711 2.5 38.9 1.0 O A:HOH531 2.5 42.8 1.0 O A:HOH707 2.6 42.2 1.0 O A:HOH702 2.8 33.0 1.0 O A:HOH623 2.8 36.4 1.0 C A:ASN145 3.6 23.3 1.0 CA A:SER146 4.3 21.7 1.0 NH2 A:ARG155 4.3 21.9 1.0 N A:SER146 4.4 22.2 1.0 OE2 A:GLU149 4.4 29.4 1.0 O A:HOH747 4.5 37.4 1.0 CA A:ASN145 4.7 23.9 1.0 CB A:ASN145 4.7 25.8 1.0 O A:HOH508 4.8 35.4 1.0 O A:HOH528 4.9 28.1 1.0

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure Mimicking the H6H Cyclization Ferryl Complex To Be Published.